Drug Insight: biological effects of botulinum toxin A in the lower urinary tract

  title={Drug Insight: biological effects of botulinum toxin A in the lower urinary tract},
  author={Michael B Chancellor and Clare Juliet Fowler and Apostolos Apostolidis and William C. de Groat and Christopher Patrick Smith and George T. Somogyi and Kei Roger Aoki},
  journal={Nature Clinical Practice Urology},
Botulinum toxins can effectively and selectively disrupt and modulate neurotransmission in striated muscle. Recently, urologists have become interested in the use of these toxins in patients with detrusor overactivity and other urological disorders. In both striated and smooth muscle, botulinum toxin A (BTX-A) is internalized by presynaptic neurons after binding to an extracellular receptor (ganglioside and presumably synaptic vesicle protein 2C). In the neuronal cytosol, BTX-A disrupts fusion… CONTINUE READING


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