Drug Insight: aggrecanases as therapeutic targets for osteoarthritis

  title={Drug Insight: aggrecanases as therapeutic targets for osteoarthritis},
  author={Amanda J Fosang and Christopher B Little},
  journal={Nature Clinical Practice Rheumatology},
In healthy cartilage, effective weight-bearing requires a high concentration of intact aggrecan. Degradation and loss of aggrecan are features of osteoarthritis (OA). It is unclear whether ADAMTS-4, ADAMTS-5, or both of these aggrecanases from the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) enzyme family, are responsible for aggrecanolysis in human OA, and at what stage of disease these enzymes are active. Several potential disease-modifying agents for OA include… CONTINUE READING


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Publications referenced by this paper.
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Identification of a novel aggrecandegrading activity in cartilage : studies of mice deficient in both ADAMTS4 and ADAMTS5

CT Appleton
Arthritis Rheum • 2008

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