Drug-Induced Liver Injury. Cholestatic Injury, Acute and Chronic.

  title={Drug-Induced Liver Injury. Cholestatic Injury, Acute and Chronic.},
  author={Claude Degott},
  journal={Pathology oncology research : POR},
  volume={3 4},
Cholestasis is the failure of bile to reach duodenum due to three different mechanisms: a. alteration of bile secretion by hepatocytes into the canaliculus with or without liver cell damage; b. obstruction of the intrahepatic bile ducts caused by diseases of ductules or small/medium bile ducts; c. obstruction of extrahepatic bile ducts. This short review focuses on drugs which may induce cholestasis by any of these mechanisms.