Drug-Induced Cutaneous Photosensitivity
@article{Moore2002DrugInducedCP, title={Drug-Induced Cutaneous Photosensitivity}, author={Douglas E. Moore}, journal={Drug Safety}, year={2002}, volume={25}, pages={345-372} }
The interaction of sunlight with drug medication leads to photosensitivity responses in susceptible patients, and has the potential to increase the incidence of skin cancer. Adverse photosensitivity responses to drugs occur predominantly as a phototoxic reaction which is more immediate than photoallergy, and can be reversed by withdrawal or substitution of the drug. The bias and inaccuracy of the reporting procedure for these adverse reactions is a consequence of the difficulty in…
246 Citations
Drug-Induced Photosensitivity—From Light and Chemistry to Biological Reactions and Clinical Symptoms
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The chemical and biological basis of drug-induced photosensitivity is reviewed, including the chemical properties, the influence of individual ranges of sunlight, the presence of melanin biopolymers, and the defense mechanisms of particular types of tested cells.
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- 2006
Phototoxicity is by far the most common reaction experienced by those individuals that are susceptible to drug-induced photosensitivity, while photoallergic reaction is less common but usually severe.
Drug-Induced Photosensitivity
- MedicineDrug safety
- 2011
The mainstay of management is prevention, including informing patients of the possibility of increased sun sensitivity and the use of sun protective measures, and once the eruption has occurred, it may be necessary to discontinued the culprit medication and treat the eruption with a potent topical corticosteroid.
Photosensitivity to Exogenous Agents
- MedicineJournal of cutaneous medicine and surgery
- 2004
ObjectiveTo better understand cutaneous photosensitivity reactions, a review of its etiologic factors, clinical characteristics, pathogenesis, and treatment modalities was undertaken.MethodsArticles…
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- 2016
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- 2012
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The pathogenetic mechanisms and causative drugs of drug-induced photosensitivity are reported, which include phototoxicity and photoallergy, and suggestions on how to improve sun exposure behaviors of patients at risk of DIP are made.
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Abstract Photosensitization can be defined as a process in which a reaction to normally harmless radiation is induced by the introduction of a specific radiation-absorbing substance (photosensitizer)…
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An updated review of the literature with respect to pathogenic mechanisms of photosensitivity, clinical manifestations, patient management, and prediction and evaluation of drug-induced photosensitivity is reported.
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Subtypes of drug-induced photosensitivity include dyschromia, pseudoporphyria, photo onycholysis, and lichenoid and telangiectatic reactions.
References
SHOWING 1-10 OF 103 REFERENCES
Cutaneous photosensitivity diseases induced by exogenous agents.
- Medicine, ChemistryJournal of the American Academy of Dermatology
- 1995
Assessment of the Phototoxicity Risk of New Drugs
- Biology
- 1997
Usually, the clinical picture associated with phototoxicity includes burning, itching, erythema, oedema, hyperpigmentation and desquamation, which is confined to the exposed areas of the skin and appear immediately after the first exposure.
Phototoxicity of nonsteroidal inflammatory drugs. Coincidence or specific mechanism
- Medicine
- 1989
The cutaneous photosensitivity to NSAIDs appears to be elicited by a phototoxicity mechanism, and the response is immediate (within minutes of exposure to ultraviolet [UV] radiation) for benoxaprofen, naproxen, and this list is extended to a new NSAID, nabumetone.
Photosensitivity Associated with Antipsychotics, Antidepressants and Anxiolytics
- MedicineDrug safety
- 1996
In order to properly diagnose photosensitivity to systemic drugs it is important to prove photosensitivity by phototesting and to rule out other causes of systemic photosensitivity such as systemic lupus erythematosus and porphyria cutanea tarda.
Photosensitivity Associated with Antibacterial Agents
- BiologyDrug safety
- 1993
Skin reactions following the interaction of photoactive drugs and ultraviolet or visible radiation are usually rapidly reversible after drug cessation, and measures such as drug dosage reduction, the wearing of photoprotective clothing and use of broad spectrum sunscreens can alleviate the problem.
Photosensitivity reactions: a case report involving NSAIDs.
- Medicine, ChemistryAmerican family physician
- 1995
A case of a photoallergic response related to the use of piroxicam is included to illustrate the presentation and management of photosensitivity reactions to nonsteroidal anti-inflammatory drugs.
Propionic acid-derived non-steroidal antiinflammatory drugs are phototoxic in vitro.
- Medicine, ChemistryPhoto-dermatology
- 1985
Members of the NSAID group, and in particular derivatives of propionic acid, are capable of inducing phototoxic reactions with UVA as well as UVB in vitro, and these results confirm clinical reports of photoreactions to members of this group.
Comparison of the DNA Damage Photoinduced by Fenofibrate and Ketoprofen, Two Phototoxic Drugs of Parent Structure
- Chemistry, BiologyPhotochemistry and photobiology
- 1998
In vitro photosensitizing properties of fenofibrate and ketoprofen were compared and their difference in efficiency as DNA breakers was compared to their relative photochemical reactivity and the quantum yield of FB photolysis was found to be eightfold lower than that of KP.