Drug-Induced Cutaneous Photosensitivity

@article{Moore2002DrugInducedCP,
  title={Drug-Induced Cutaneous Photosensitivity},
  author={Douglas E. Moore},
  journal={Drug Safety},
  year={2002},
  volume={25},
  pages={345-372}
}
  • D. Moore
  • Published 2002
  • Medicine
  • Drug Safety
The interaction of sunlight with drug medication leads to photosensitivity responses in susceptible patients, and has the potential to increase the incidence of skin cancer. Adverse photosensitivity responses to drugs occur predominantly as a phototoxic reaction which is more immediate than photoallergy, and can be reversed by withdrawal or substitution of the drug. The bias and inaccuracy of the reporting procedure for these adverse reactions is a consequence of the difficulty in… Expand
Drug-Induced Photosensitivity
TLDR
Phototoxicity is by far the most common reaction experienced by those individuals that are susceptible to drug-induced photosensitivity, while photoallergic reaction is less common but usually severe. Expand
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The chemical and biological basis of drug-induced photosensitivity is reviewed, including the chemical properties, the influence of individual ranges of sunlight, the presence of melanin biopolymers, and the defense mechanisms of particular types of tested cells. Expand
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TLDR
Mainstays of treatment are the withdrawal of the culprit drug, and avoidance of sunlight by wearing protective clothing and broadband sunscreens with UVA filters, and histopathology. Expand
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TLDR
This work reviews the drugs that have been implicated as photosensitizers, the involved mechanism, and their clinical presentations, and the main topical agents that cause contact photosensitivity are the nonsteroidal antiinflammatory drugs, whereas the main systemic drugs inducing photos sensitivity are antimicrobials, nonsteroid antiinflammatory agents, and cardiovascular drugs. Expand
Applications of photosensitizer in therapy.
Abstract Photosensitization can be defined as a process in which a reaction to normally harmless radiation is induced by the introduction of a specific radiation-absorbing substance (photosensitizer)Expand
Generation of reactive intermediates in photoallergic dermatitis
TLDR
Some specific examples of photoallergic xenobiotics include nonsteroidal anti-inflammatory drugs, antibiotics, platelet aggregation inhibitors, and sunscreens taken from the scientific literature published during the last decade, with particular emphasis on the most recent articles. Expand
Photoactivation of a compound results in the excitation applications of Photosensitizer in therapy
Photosensitization can be defined as a process in which a reaction to normally harmless radiation is induced by the introduction of a specific radiation-absorbing substance (photosensitizer) thatExpand
Latest Evidence Regarding the Effects of Photosensitive Drugs on the Skin: Pathogenetic Mechanisms and Clinical Manifestations
TLDR
An updated review of the literature with respect to pathogenic mechanisms of photosensitivity, clinical manifestations, patient management, and prediction and evaluation of drug-induced photosensitivity is reported. Expand
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