Drug- Induced Behavioural Disinhibition

@article{Bond1998DrugIB,
  title={Drug- Induced Behavioural Disinhibition},
  author={Alyson J. Bond},
  journal={CNS Drugs},
  year={1998},
  volume={9},
  pages={41-57}
}
  • A. Bond
  • Published 1998
  • Medicine, Psychology
  • CNS Drugs
SummaryBehavioural disinhibition implies the loss of restraint over some form of social behaviour. Such disinhibition can be drug induced and, on rare occasions, lead to extreme acts of aggression or violence. Examples of behavioural disinhibition are often considered paradoxical and rare reactions to drugs, but they may in fact be a more severe behavioural manifestation of a general effect that the drug has on emotions and behaviour. However, the incidence of drug-induced behavioural… 
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References

SHOWING 1-10 OF 122 REFERENCES
Disinhibition, amnestic reactions, and other adverse reactions secondary to triazolam: a review of the literature.
TLDR
There is little scientific evidence that triazolam is associated with disinhibitory or other adverse reactions at a greater frequency than other benzodiazepines.
Sexual Disinhibition with L-Tryptophan
TLDR
A 72 year old married white male with a 14 year history of recurrent unipolar depression and two family history of affective disorder, was admitted to the Kingston Psychiatric Hospital with symptoms of a severe agitated depression and was discharged fully recovered from depression on clomipramine 150 mg/day.
Sexual Disinhibition during Treatment with a Benzodiazepine: A Case Report
TLDR
The patient became clearly sexually disinhibited while treated with clonazepam, a high potency anti-anxiety benzodiazepine, and her “inappropriate” sexual behavior ceased when the medication was discontinued.
Disinhibitory psychopathology: a new perspective and a model for research.
TLDR
The syndrome produced by lesion of the septum in animals can serve as a functional research model of human disinhibitory psychopathology and a program of experimentati on utilizing this animal model is outlined.
Serotonin Syndrome
TLDR
The serotonin syndrome provides a heuristic model of the putative mode of action of antidepressants and provides the physical and objective expression of an antidepressant-induced increase in serotonin neurotransmission.
Drug Choice in Depression
TLDR
Although drug safety monitoring shows that SSRIs only rarely cause serious problems, some of the drugs are relatively new and it is, therefore, necessary to remain alert to the possibility of hitherto unrecognised adverse effects, especially after long term use.
Effects of fluoxetine on aggressive behavior of adult inpatients with mental retardation and epilepsy.
TLDR
It is suggested that the clinician who treats mentally retarded patients with impulsive aggressive behavior should remain aware that fluoxetine may have diverse effects on aggression that vary over time and interindividually.
Safety and Side-effects of Alprazolam Controlled Study in Agoraphobia with Panic Disorder
TLDR
Alprazolam caused side-effects and adverse effects during treatment but many patients were willing to accept these, and the drop-out rate was low.
Can a rapidly-eliminated hypnotic cause daytime anxiety?
TLDR
The very short life of triazolam, leading to daytime withdrawal symptoms, may account for some of the observations, but enhancement of benzodiazepine inverse agonist activity is also hypothesized.
Mania induced by citalopram.
TLDR
This letter describes a manic episode induced by citalopram, a major depressive episode of moderate intensity developed in a 52-year-old man with no personal or family history of depression or bipolar disorder, who required psychiatric hospitalization because of a high suicide risk.
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