Drug Holidays From ADHD Medication

@article{Ibrahim2015DrugHF,
  title={Drug Holidays From ADHD Medication},
  author={Kinda Ibrahim and Parastou Donyai},
  journal={Journal of Attention Disorders},
  year={2015},
  volume={19},
  pages={551 - 568}
}
Objective: ADHD is managed by stimulants that are effective but can cause growth retardation. Prescribers should ideally monitor children and trial a “drug holiday” to enable catch-up growth. Our aim was to map the experience of drug holidays from ADHD medication in children and adolescents. Method: A comprehensive search of the literature identified 22 studies published during the period 1972 to 2013. Results: Drug holidays are prevalent in 25% to 70% of families and are more likely to be… 
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‘Education’ and ‘enablement’ interventions were identified as key activities targeting all three components, which could feasibly increase uptake of practitioner-initiated planned drug holidays from methylphenidate.
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Long-term treatment with MPH can result in reduction in height and weight, however, effect sizes are small with possible minimal clinical impact, which may help to clarify the underlying biological drivers and specific mediators and moderators.
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References

SHOWING 1-10 OF 62 REFERENCES
Weekend holidays during methylphenidate use in ADHD children: a randomized clinical trial.
TLDR
It is suggested that weekend holidays during MPH administration reduce the side effects of insomnia and appetite suppression without a significant increase in symptoms, either on weekends or in the first school day after them.
Growth on stimulant medication; clarifying the confusion: a review
  • A. Poulton
  • Medicine
    Archives of Disease in Childhood
  • 2005
Aims: To get an overview of the studies of growth in height in children with attention deficit hyperactivity disorder (ADHD) treated with stimulant medication, to establish the consistencies and to
To stop or not to stop? How long should medication treatment of attention-deficit hyperactivity disorder be extended?
TLDR
There is limited and inconsistent evidence for long-term advantage of medication treatment beyond symptom control, such as improved social functioning, academic achievement, employment status and less adverse psychiatric outcome.
Cessation of attention deficit hyperactivity disorder drugs in the young (CADDY)--a pharmacoepidemiological and qualitative study.
TLDR
The prevalence of prescribing by GPs to patients with ADHD dropped significantly from age 15 to 21, and the fall in prescribing was greater than the reported age-related decrease in symptoms, raising the possibility that treatment is prematurely discontinued in some young adults where ADHD symptoms persist.
Medication holidays.
  • R. Howland
  • Medicine
    Journal of psychosocial nursing and mental health services
  • 2009
TLDR
To partially reverse the physiological adaptive effects that result from chronic pharmacological stimulation, medication holidays have been hypothesized to "resensitize" neurons to the acute pharmacological effects of a drug.
Effects of long-term psychostimulant medication on growth of children with ADHD.
TLDR
Although z-scores for weight showed significant changes over the 2 years of treatment, further analysis of the changes did not reach clinical significance, generally parents and providers can be reassured that growth changes with long-term stimulant therapy are not clinically significant for a diverse group of children with ADHD.
Moderators and mediators of long-term adherence to stimulant treatment in children with ADHD.
TLDR
Adherence to stimulant medications is a significant factor in the long-term treatment of children with ADHD and response to treatment at school, measured at 12 months, was investigated as a mediation of adherence.
ADHD treatment with once-daily OROS methylphenidate: final results from a long-term open-label study.
TLDR
Sustained effectiveness of OROS MPH was maintained for up to 24 months with minimal effects on growth, tics, vital Signs, vital signs, or laboratory test values, according to parent and investigator assessments.
Methylphenidate: Use in Daily Practice
TLDR
The percentage of children having a good compliance calculated on the basis of pharmacy records is rather low, partly the result of the decreased use of methylphenidate in the weekends and holidays.
Selective serotonin reuptake inhibitor-induced sexual dysfunction: efficacy of a drug holiday.
  • A. Rothschild
  • Psychology, Medicine
    The American journal of psychiatry
  • 1995
TLDR
For some patients taking sertraline and paroxetine who experience sexual dysfunction side effects, brief drug holidays may allow for significant improvement in sexual functioning without a significant return of depressive symptoms.
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