Drug Distribution in Human Skin Using Two Different In Vitro Test Systems: Comparison with In Vivo Data

@article{Wagner2000DrugDI,
  title={Drug Distribution in Human Skin Using Two Different In Vitro Test Systems: Comparison with In Vivo Data},
  author={Heike Wagner and K L Kostka and Claus-Michael Lehr and Ulrich F. Sch{\"a}fer},
  journal={Pharmaceutical Research},
  year={2000},
  volume={17},
  pages={1475-1481}
}
Purpose. Two in vitro test systems used to study drug penetration into human skin—the Franz diffusion cell (FD-C) and the Saarbruecken penetration model (SB-M)—were evaluated, and the results were compared with data gained under analogous in vivo conditions. Methods. Excised human skin was used in all in vitro experiments. Flufenamic acid dissolved in wool… CONTINUE READING