Drug Distribution and Biliary Excretion Pattern of a Cyclic Somatostatin Analog: A Comparison of 14C Labeled Drug and a 131I lodinated Drug Analog

@article{Caldwell1985DrugDA,
  title={Drug Distribution and Biliary Excretion Pattern of a Cyclic Somatostatin Analog: A Comparison of 14C Labeled Drug and a 131I lodinated Drug Analog},
  author={Larry J. Caldwell and Alan Parr and Robert M. Beihn and Bushra J. Agha and Arthur Roman Mlodozeniec and Michael Jay and George A. Digenis},
  journal={Pharmaceutical Research},
  year={1985},
  volume={2},
  pages={80-83}
}
A cyclic somatostatin analog was compared to an iodinated analog of the same compound with respect to organ distribution and biliary excretion in the rat. The cyclic hexapeptide was radiolabeled with either 14C or 131I (tyrosine). Organ distribution of the iodinated compound as a function of time was nearly identical to that observed for the non-iodinated compound. Results indicated a rapid uptake by the liver and subsequent rapid excretion of the intact peptide in bile. Activity in other… CONTINUE READING

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