Corpus ID: 212512196

Drug Disposition in Diseases Altering CYP450-Mediated Metabolism

  title={Drug Disposition in Diseases Altering CYP450-Mediated Metabolism},
  author={N. Hamdy and S. Hegazy and G. Ahmed and Adam and Nawal MK halafallah},
  • N. Hamdy, S. Hegazy, +2 authors Nawal MK halafallah
  • Published 2017
  • Submit Manuscript | Abbreviations: AhR: Aryl Hydrocarbon Receptor; Arnt: Nuclear Translocator; CLP: Cecal Ligation and Puncture; CVB3: Coxsackievirus B3; CRP: C-Reactive Protein; CYP-450: Cytochrome P-450; ECOD: Ethoxycoumarin O-Deethylase; GH: Growth Hormone; IMND: Imipramine N-Demethylase; iNOS: inducible Nitric Oxide Synthetase; icv: intracerebroventricularly; IFN-γ: Interferon γ; IL: Interleukin; KC: Kupffer Cells; L-NAME: Nitro L-Arginine Methyl Ester; LPS… CONTINUE READING


    Hepatic cytochrome P-450 expression in tumor necrosis factor-alpha receptor (p55/p75) knockout mice after endotoxin administration.
    • 70
    Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes.
    • 221
    • Highly Influential
    Nitric oxide differentially affects constitutive cytochrome P450 isoforms in rat liver.
    • 76
    Hepatic cytochrome P450 is directly inactivated by nitric oxide, not by inflammatory cytokines, in the early phase of endotoxemia.
    • 86
    Inhibition of cytochromes P4501A by nitric oxide.
    • 202
    • PDF
    Drug-Cytokine Interactions
    • 8
    Pretranslational down-regulation of cytochromes P450 2C11 and 3A2 in male rat liver by tumor necrosis factor alpha.
    • 54