Drug Delivery Systems: Entering the Mainstream
@article{Allen2004DrugDS, title={Drug Delivery Systems: Entering the Mainstream}, author={Theresa M. Allen and Pieter R. Cullis}, journal={Science}, year={2004}, volume={303}, pages={1818 - 1822} }
Drug delivery systems (DDS) such as lipid- or polymer-based nanoparticles can be designed to improve the pharmacological and therapeutic properties of drugs administered parenterally. Many of the early problems that hindered the clinical applications of particulate DDS have been overcome, with several DDS formulations of anticancer and antifungal drugs now approved for clinical use. Furthermore, there is considerable interest in exploiting the advantages of DDS for in vivo delivery of new drugs…
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References
SHOWING 1-10 OF 56 REFERENCES
Small-scale systems for in vivo drug delivery
- BiologyNature Biotechnology
- 2003
Micro- and nanotechnologies are enabling the design of novel methods such as radio-frequency addressing of individual molecules or the suppression of immune response to a release device, but current challenges include the need to balance the small scale of the devices with the quantities of drugs that are clinically necessary.
Chemical approaches to triggerable lipid vesicles for drug and gene delivery.
- Biology, ChemistryAccounts of chemical research
- 2003
This work reviews the chemistries that have recently been applied to exploit the pH and redox potential triggers so as to release vesicle contents in the appropriate biological location.
The dawning era of polymer therapeutics
- Biology, ChemistryNature Reviews Drug Discovery
- 2003
The successful clinical application of polymer–protein conjugates, and promising clinical results arising from trials with polymer–anticancer-drug conjugate, bode well for the future design and development of the ever more sophisticated bio-nanotechnologies that are needed to realize the full potential of the post-genomic age.
Effect of pegylation on pharmaceuticals
- Biology, ChemistryNature Reviews Drug Discovery
- 2003
How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
Myths concerning the use of cationic liposomes in vivo
- Biology
- 2003
This review will highlight the features of liposomes that contribute to successful delivery, gene expression and efficacy and will allow broad use ofliposomal complexes to treat or cure human diseases or disorders.
Recent trends in the use of polysaccharides for improved delivery of therapeutic agents: pharmacokinetic and pharmacodynamic perspectives.
- Biology, ChemistryCurrent pharmaceutical biotechnology
- 2003
Four recent examples of polysaccharide-based delivery systems involving specific drugs/imaging agents are reviewed in detail in terms of their development, pharmacokinetics, and pharmacodynamics, suggesting that macromolecular poly Saccharides are promising agents for improving drug delivery.
Long-circulating and target-specific nanoparticles: theory to practice.
- BiologyPharmacological reviews
- 2001
The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
Nanoparticulate systems for brain delivery of drugs.
- Biology, ChemistryAdvanced drug delivery reviews
- 2001
Ligand-targeted therapeutics in anticancer therapy
- Biology, MedicineNature Reviews Cancer
- 2002
Cytotoxic chemotherapy or radiotherapy of cancer is limited by serious, sometimes life-threatening, side effects that arise from toxicities to sensitive normal cells because the therapies are not…
Tumor-Targeted Gene Transfer with DNA Polyplexes
- Biology, ChemistrySomatic cell and molecular genetics
- 2002
Polyplexes based on polyethylenimine, shielded with polyethylene glycol, and linked to the receptor binding ligands transferrin (Tf) or epidermal growth factor (EGF) were found to mediate efficient gene transfer into tumor cell lines in a receptor-dependent and cell-cycle-dependent manner.