Drug Delivery Systems: Entering the Mainstream

@article{Allen2004DrugDS,
  title={Drug Delivery Systems: Entering the Mainstream},
  author={Theresa M. Allen and Pieter R. Cullis},
  journal={Science},
  year={2004},
  volume={303},
  pages={1818 - 1822}
}
Drug delivery systems (DDS) such as lipid- or polymer-based nanoparticles can be designed to improve the pharmacological and therapeutic properties of drugs administered parenterally. Many of the early problems that hindered the clinical applications of particulate DDS have been overcome, with several DDS formulations of anticancer and antifungal drugs now approved for clinical use. Furthermore, there is considerable interest in exploiting the advantages of DDS for in vivo delivery of new drugs… Expand
Targeting Liposomal Nanomedicine to Cancer Therapy
TLDR
Recent advances in this field involving conventional anticancer drugs as well as the new genetic drugs with the potentials to offer new treatments in area of cancer therapy are discussed. Expand
Triggered Nanoparticles as Therapeutics.
TLDR
This review, which highlights recent examples of the use of triggered release strategies of engineered nanomaterials for in vitro and in vivo applications, can be achieved through both endogenous and exogenous activation. Expand
Nanoscale delivery systems for multiple drug combinations in cancer.
TLDR
Some general considerations for optimizing multiply drug delivery, including drug-release profiles and loading strategies are discussed, which are likely to be potential targets in combination therapy as well. Expand
Applications of carbon nanotubes in drug delivery.
TLDR
Carbon nanotubes have emerged as a new alternative and efficient tool for transporting and translocating therapeutic molecules and hold great potential in the field of nanobiotechnology and nanomedicine. Expand
POLYMERS FOR DRUG DELIVERY SYSTEM : A REVIEW
Pharmaceutical invention and research are now increasingly focusing on delivery systems which enhance desirable therapeutic objectives while minimizing side effects. Drug delivery systems, rangingExpand
Carrier-mediated delivery of peptidic drugs for cancer therapy
TLDR
The various carrier-mediated methods used for delivery of peptide and protein drugs, with emphasis on liposomal and microspherical drug delivery systems are discussed, with a brief look at the types of peptidic drugs currently in use clinically. Expand
Protein and peptide-based delivery systems
Abstract Limited therapeutic efficacy of biomolecular drugs has resulted in the development of various drug delivery systems to protect them from degradation and renal clearance. Protein andExpand
Nanotechnology: A Focus on Nanoparticles as a Drug Delivery System
This review will provide an in-depth discussion on the previous development of nanoparticle-based drug delivery systems (DDS) and discuss original research data that includes the therapeuticExpand
Micro and nano drug delivery systems in cancer therapyArticle
TLDR
A great number of new drug delivery technologies have been optimised including the micro and nano-systems as well as polymer conjugation, which would not only improve drug administration and the efficiency and safety of conventional chemotherapies, but also revolutionize the pharmaceutical and biomedical industries in cancer therapy. Expand
Polymeric nanomaterials in drug delivery
Abstract Nano-drug delivery systems are nanoscale materials such as dendrimers, polymeric nanoparticles, liposomes, niosomes, and nanocapsules that firmly entered the realm of drug delivery toExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 62 REFERENCES
Small-scale systems for in vivo drug delivery
TLDR
Micro- and nanotechnologies are enabling the design of novel methods such as radio-frequency addressing of individual molecules or the suppression of immune response to a release device, but current challenges include the need to balance the small scale of the devices with the quantities of drugs that are clinically necessary. Expand
Chemical approaches to triggerable lipid vesicles for drug and gene delivery.
TLDR
This work reviews the chemistries that have recently been applied to exploit the pH and redox potential triggers so as to release vesicle contents in the appropriate biological location. Expand
The dawning era of polymer therapeutics
  • R. Duncan
  • Chemistry, Medicine
  • Nature Reviews Drug Discovery
  • 2003
TLDR
The successful clinical application of polymer–protein conjugates, and promising clinical results arising from trials with polymer–anticancer-drug conjugate, bode well for the future design and development of the ever more sophisticated bio-nanotechnologies that are needed to realize the full potential of the post-genomic age. Expand
Effect of pegylation on pharmaceuticals
TLDR
How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed. Expand
Myths concerning the use of cationic liposomes in vivo
Varied results have been obtained using cationic liposomes for in vivo delivery. Furthermore, optimisation of cationic liposomal complexes for in vivo applications is complicated, involving manyExpand
Recent trends in the use of polysaccharides for improved delivery of therapeutic agents: pharmacokinetic and pharmacodynamic perspectives.
  • R. Mehvar
  • Chemistry, Medicine
  • Current pharmaceutical biotechnology
  • 2003
TLDR
Four recent examples of polysaccharide-based delivery systems involving specific drugs/imaging agents are reviewed in detail in terms of their development, pharmacokinetics, and pharmacodynamics, suggesting that macromolecular poly Saccharides are promising agents for improving drug delivery. Expand
Long-circulating and target-specific nanoparticles: theory to practice.
TLDR
The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed. Expand
Nanoparticulate systems for brain delivery of drugs.
TLDR
Intravenously injected doxorubicin-loaded polysorbate 80-coated nanoparticles were able to lead to a 40% cure in rats with intracranially transplanted glioblastomas 101/8, and may be especially helpful for the treatment of the disseminated and very aggressive brain tumors. Expand
Ligand-targeted therapeutics in anticancer therapy
  • T. Allen
  • Medicine
  • Nature Reviews Cancer
  • 2002
Cytotoxic chemotherapy or radiotherapy of cancer is limited by serious, sometimes life-threatening, side effects that arise from toxicities to sensitive normal cells because the therapies are notExpand
Tumor-Targeted Gene Transfer with DNA Polyplexes
TLDR
Polyplexes based on polyethylenimine, shielded with polyethylene glycol, and linked to the receptor binding ligands transferrin (Tf) or epidermal growth factor (EGF) were found to mediate efficient gene transfer into tumor cell lines in a receptor-dependent and cell-cycle-dependent manner. Expand
...
1
2
3
4
5
...