Drug Addiction: The Yin and Yang of Hedonic Homeostasis

@article{Koob1996DrugAT,
  title={Drug Addiction: The Yin and Yang of Hedonic Homeostasis},
  author={G. Koob},
  journal={Neuron},
  year={1996},
  volume={16},
  pages={893-896}
}
  • G. Koob
  • Published 1996
  • Psychology, Medicine
  • Neuron
Drug addiction is a chronic relapsing disorder, and relapse is associated with states of craving and protracted abstinence that are difficult to define but reflect some prolonged post-acute withdrawal perturbation or vulnerability to reinstatement of drug-taking behavior and ultimately compulsive use. There may be either a residual deficit state or a sensitization of the reward system to stimuli that predict drug effects or both. One could speculate that the combination would be particularly… Expand
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