Drug–Target Kinetics in Drug Discovery

Abstract

The development of therapies for the treatment of neurological cancer faces a number of major challenges including the synthesis of small molecule agents that can penetrate the blood-brain barrier (BBB). Given the likelihood that in many cases drug exposure will be lower in the CNS than in systemic circulation, it follows that strategies should be employed… (More)
DOI: 10.1021/acschemneuro.7b00185

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