Drug‐induced photosensitivity to bicalutamide – case report and review of the literature

  title={Drug‐induced photosensitivity to bicalutamide – case report and review of the literature},
  author={Kasumi Lee and Yoshiko Oda and Masanobu Sakaguchi and Akihisa Yamamoto and Chikako Nishigori},
Abstract Hormone therapy is highly important in the treatment of prostate cancer. Flutamide is used as an anti-androgen drug for prostate cancer; however, it has been reported that flutamide sometimes causes photosensitivity and severe liver dysfunction. In contrast, bicalutamide seldom causes these side-effects. Therefore, in recent years, flutamide has been replaced with bicalutamide as the most widely used anti-androgen drug for prostate cancer therapy. However, a few cases of… Expand
3 Citations
Drug-Induced Photosensitivity—An Update: Culprit Drugs, Prevention and Management
A large number of medications have been implicated as causes of photosensitivity, many with convincing clinical and scientific supporting evidence, including the results of phototesting, photopatch testing and rechallenge testing. Expand
Drug-Induced Photosensitivity—From Light and Chemistry to Biological Reactions and Clinical Symptoms
The chemical and biological basis of drug-induced photosensitivity is reviewed, including the chemical properties, the influence of individual ranges of sunlight, the presence of melanin biopolymers, and the defense mechanisms of particular types of tested cells. Expand
Quantum mechanical, spectroscopic and molecular docking studies of N-[4-cyano-3-(trifluoromethyl) phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
Abstract The title compound N-[4-cyano-3-(trifluoromethyl) phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide was characterized by FT-IR, FT-RAMAN, UV, 1H NMR and 13C NMR spectralExpand


Photosensitive drug eruption induced by bicalutamide within the UVB action spectrum.
Bicalutamide is a non-steroidal, anti-androgenic drug used for the treatment of prostatic carcinoma and has been reported to cause photosensitivity in mice. Expand
Adverse events associated with hormonal therapy for prostate cancer.
With expanding indications for androgen deprivation therapy for the treatment of prostate cancer, it is imperative that health care providers be cognizant of the possible adverse effects of therapy,Expand
Photosensitivity due to bicalutamide
  • J Environ Dermatol Cutan Allergol 2007;
  • 2007
Adverse Event Report Form: Casodex Tablet
  • AstraZeneca