Drug‐induced hearing loss: a case/non‐case study in the French pharmacovigilance database

@article{Favrelire2020DruginducedHL,
  title={Drug‐induced hearing loss: a case/non‐case study in the French pharmacovigilance database},
  author={Sylvie Favreli{\`e}re and Paul Delaunay and Jean-Pascal Lebreton and Franck Rouby and Martine Atzenhoffer and Claire Lafay-Chebassier and Marie Christine P{\'e}rault-Pochat},
  journal={Fundamental \& Clinical Pharmacology},
  year={2020},
  volume={34}
}
Hearing loss is defined as a decrease in the ability to perceive sounds which can occur suddenly or gradually and affects one ear or both. It is related to various etiologies, in particular drugs. The identification of all drugs that could be associated with hearing loss is essential for the patients' life quality. The objective of our study was to identify signals of hearing loss involving drugs approved in the last 20 years. The occurrence in association with drugs known for their ototoxicity… 

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References

SHOWING 1-10 OF 66 REFERENCES

Drug-induced hearing loss.

TLDR
Various factors increase the risk of drug-related hearing loss, including age, dehydration, reduced drug elimination (especially due to renal failure), and co-administration of other ototoxic drugs.

Irreversible Atorvastatin‐Associated Hearing Loss

TLDR
This case report describes the first case of progressive, irreversible hearing loss in a 32‐year‐old man 18 months after starting atorvastatin therapy and recommends that clinicians and patients be aware of the risk of atorVastatin‐associated tinnitus and permanent hearing loss.

Drug‐induced progressive multifocal leukoencephalopathy: a case/noncase study in the French pharmacovigilance database

TLDR
An association between PML and some immunosuppressant drugs was found as expected, but also with antineoplastic agents and glucocorticoids, and an important delay of PML onset after stopping treatment is suspected and should alert prescribers.

Ototoxicity: A Challenge in Diagnosis and Treatment

TLDR
An efficient application of ototoxicity monitoring and treatment protocol is described as an attempt to reduce the challenges in diagnosis and management of Ototoxicity.

Ototoxic Adverse Drug Reactions: A Disproportionality Analysis Using the Italian Spontaneous Reporting Database

TLDR
An analysis of ADR reports describing drug-induced ototoxicity from the Italian spontaneous reporting system from 2001 to 2017 found significant adjusted RORs for drugs for cardiovascular disorders, urologicals, teriparatide, amikacin, prulifloxacin and isoniazid, cisplatin, hormone antagonists, tacrolimus, pomalidomide, tramadol, and antidepressants.

Ototoxicity in children receiving platinum chemotherapy: underestimating a commonly occurring toxicity that may influence academic and social development.

TLDR
Traditional reporting of toxicity data (CTCAE) has under-reported ototoxicity and minimized the significance of hearing loss in children, especially in patients younger than 5 years.

Sudden-Onset Sensorineural Hearing Loss after Immunization

TLDR
A large-scale analysis applying a case-centered method did not detect any association between SSHL and previous receipt of TIV or other vaccines.

Pharmacological drugs inducing ototoxicity, vestibular symptoms and tinnitus: a reasoned and updated guide.

TLDR
The present work on drug-induced ototoxicity, tinnitus and vertigo represents the update and revision of a previous guide to adverse drug reactions for italian physicians (2005), and is useful to any physician, regardless of the country he/she operates in.

Protection for medication-induced hearing loss: the state of the science

TLDR
Vitamins and antioxidants are the most common agents currently evaluated for drug-induced ototoxicity intervention by targeting the oxidative stress pathway that leads to cochlear cell death and hearing loss, however, other strategies, including steroid treatment and reduction of ototoxic properties of the primary drugs, are discussed.

Audiological Monitoring of Patients Receiving Ototoxic Drugs

TLDR
Noise exposure has a synergistic effect, increasing the risk of hearing loss during therapeutic treatment with ototoxic drugs, and the effects can be temporary, but are often permanent.
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