Drp1 loss-of-function reduces cardiomyocyte oxygen dependence protecting the heart from ischemia-reperfusion injury.

@article{Zepeda2014Drp1LR,
  title={Drp1 loss-of-function reduces cardiomyocyte oxygen dependence protecting the heart from ischemia-reperfusion injury.},
  author={Ramiro J. Zepeda and Jovan Kuzmicic and Valentina Parra and Rodrigo A. Troncoso and Christian Pennanen and Jaime A. Riquelme and Zully Pedrozo and Mario Chiong and Gina L S{\'a}nchez and Sergio Lavandero},
  journal={Journal of cardiovascular pharmacology},
  year={2014},
  volume={63 6},
  pages={477-87}
}
Mitochondria are key organelles for ATP production in cardiomyocytes, which is regulated by processes of fission and fusion. We hypothesized that the mitochondria fusion protein dynamin-related protein 1 (Drp1) inhibition, attenuates ischemia-reperfusion (I/R) injury through modifications in mitochondrial metabolism. Rats were subjected to I/R through coronary artery ligation, and isolated cardiomyocytes were treated with an ischemia-mimicking solution. In vivo, cardiac function, myocardial… CONTINUE READING

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