Droxinostat, a Histone Deacetylase Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cell Lines via Activation of the Mitochondrial Pathway and Downregulation of FLIP.

@article{Liu2016DroxinostatAH,
  title={Droxinostat, a Histone Deacetylase Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cell Lines via Activation of the Mitochondrial Pathway and Downregulation of FLIP.},
  author={Jing Liu and Guangming Li and Xiang Wen Wang and Liang Wang and Rui Zhao and Juanxia Wang and Yin Kong and Jie Ding and Juan Li and Lingyi Zhang},
  journal={Translational oncology},
  year={2016},
  volume={9 1},
  pages={70-78}
}
BACKGROUND The current chemotherapeutic outcomes for hepatocellular carcinoma (HCC) are not encouraging, and long-term survival of this patient group remains poor. Recent studies have demonstrated the utility of histone deacetylase inhibitors that can disrupt cell proliferation and survival in HCC management. However, the effects of droxinostat, a type of… CONTINUE READING