Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis.

@article{Ely2003DrotrecoginA,
  title={Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis.},
  author={Eugene W. Ely and P. -F. Laterre and Derek C. Angus and Jeffrey D. Helterbrand and Howard B. Levy and J. F. ancois Dhainaut and Jean-Louis Vincent and William Louis Macias and Gordon R. Bernard},
  journal={Critical care medicine},
  year={2003},
  volume={31 1},
  pages={
          12-9
        }
}
OBJECTIVE To assess the effects of drotrecogin alfa (activated) therapy, a recombinant human activated protein C, across clinically relevant subpopulations in a randomized, phase 3, placebo-controlled study of patients with severe sepsis (recombinant human activated protein C worldwide evaluation in severe sepsis [PROWESS]). DESIGN Univariate and multivariable analysis of prospectively defined subgroups from the PROWESS study. SETTING A total of 164 medical centers in 11 countries… CONTINUE READING

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