• DOI:10.1080/13697130500330341
Corpus ID: 42837148

Drospirenone in combination with estrogens: for contraception and hormone replacement therapy

@article{Oelkers2005DrospirenoneIC,
  title={Drospirenone in combination with estrogens: for contraception and hormone replacement therapy},
  author={W. Oelkers},
  journal={Climacteric},
  year={2005},
  volume={8},
  pages={19 - 27}
}

• W. Oelkers
• Published 2005
• Medicine
• Climacteric

Progesterone has a high affinity for the mineralocorticoid receptor and is an antagonist of aldosterone. Almost all synthetic progestogens are devoid of an antimineralocorticoid effect, and are unable to antagonize the salt-retaining effect of estrogens. This property could be one cause of the weight gain and increase in blood pressure associated with the use of combined oral contraceptives and, in some susceptible women, with postmenopausal hormone replacement therapy (HRT). This review… Expand