• DOI:10.2165/00003495-200767050-00001
Corpus ID: 22985078

Drospirenone for Oral Contraception and Hormone Replacement Therapy

@article{Motivala2012DrospirenoneFO,
  title={Drospirenone for Oral Contraception and Hormone Replacement Therapy},
  author={A. Motivala and B. Pitt},
  journal={Drugs},
  year={2012},
  volume={67},
  pages={647-655}
}

• A. Motivala, B. Pitt
• Published 2012
• Medicine
• Drugs

The use of combined estrogen/progesterone has been shown to result in an increased cardiovascular risk in randomised double-blinded trials. However, these studies used oral progestogen (progestin) preparations, which lack anti-mineralocorticoid activity and have suboptimal anti-androgenic activity compared with progesterone. Drospirenone is a unique progestogen that has clinically been shown to have anti-mineralocorticoid/anti-androgenic effects. Drospirenone in combination with estrogen is… Expand