Drospirenone and its antialdosterone properties

@article{Genazzani2007DrospirenoneAI,
  title={Drospirenone and its antialdosterone properties},
  author={A. Genazzani and P. Mannella and T. Simoncini},
  journal={Climacteric},
  year={2007},
  volume={10},
  pages={11 - 18}
}
Drospirenone is a unique progestogen derived from 17α-spirolactone, with a pharmacologic profile very similar to that of endogenous progesterone. In contrast with other available progestins, drospirenone is a progestogen with aldosterone receptor antagonism (PARA) through its affinity for the mineralocorticoid receptor. It is thus able to act on the renin–angiotensin–aldosterone system (RAAS), which prevents excessive sodium loss and regulates blood pressure. Estrogen acts on the RAAS to… Expand
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