Drospirenone: a Novel Progestogen with Antimineralocorticoid and Antiandrogenic Activity
@article{Muhn1995DrospirenoneAN, title={Drospirenone: a Novel Progestogen with Antimineralocorticoid and Antiandrogenic Activity}, author={Peter Muhn and Ulrike Fuhrmann and Karl Heinrich Fritzemeier and Rolf Krattenmacher and Ekkehardt Schillinger}, journal={Annals of the New York Academy of Sciences}, year={1995}, volume={761} }
Drospirenone (ZK 30595; 6 beta, 7 beta, 15 beta, 16 beta-dimethylen-3-oxo-17 alpha-pregn-4-ene-21, 17-carbolactone) is a novel progestogen under clinical development. Drospirenone is characterized by an innovative pharmacodynamic profile which is very closely related to that of progesterone. Potential applications include oral contraception, hormone replacement therapy and treatment of hormonal disorders. The pharmacological properties of drospirenone were investigated in vitro by receptor…Â
186 Citations
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The combined actions of drospirenone on sodium and water retention and cardiovascular parameters make it a more attractive therapeutic option as a component of hormone replacement therapy than other synthetic progestins.
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Drospirenone is not only a safe option for women using oral contraceptives or HRT, but it may offer new medical benefits, via its antimineralocorticoid and antialdosterone effects and its potential to decrease water retention and blood pressure.
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Drospirenone, which has pharmacodynamic properties very similar to those of progesterone, has been developed as a combined oral contraceptive and may counteract the negative effect of androgens on hair growth, lipid changes, insulin and, possibly, body composition in postmenopausal women.
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Drospirenone exerts a potent antiadipogenic effect that is related to an alteration of the transcriptional control of adipogenesis via an antagonistic effect on the MR, and has promise as a novel therapeutic option for the control of excessive adipose tissue deposition and its related metabolic complications.
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