Drospirenone/Ethinylestradiol 3mg/20µg (24/4 Day Regimen)
@article{Fenton2012DrospirenoneEthinylestradiol3, title={Drospirenone/Ethinylestradiol 3mg/20µg (24/4 Day Regimen)}, author={Caroline Fenton and Keri David. Wellington and Marit D. Moen and Dean M. Robinson}, journal={Drugs}, year={2012}, volume={67}, pages={1749-1765} }
SummaryAbstractDrospirenone 3mg with ethinylestradiol 20µg (Yaz®) is a low-dose combined oral contraceptive (COC) administered in a regimen of 24 days of active tablets followed by a short hormone-free interval (4 days; 24/4 regimen). Drospirenone, unlike other synthetic progestogens used in COCs, is a 17α-spirolactone derivative and a 17α-spironolactone analogue with antimineralocorticoid and antiandrogenic properties. Drospirenone/ethinylestradiol 3mg/20µg (24/4) is approved in the US for the…
22 Citations
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References
SHOWING 1-10 OF 50 REFERENCES
Inhibition of ovulation by a novel progestogen (drospirenone) alone or in combination with ethinylestradiol
- MedicineThe European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
- 2000
The combination of 3 mg drospirenone/30 μg ethinylestradiol (Yasmin ®, Schering AG) reliably inhibits ovulation, with a low frequency of follicular maturation, and provides a reasonable safety margin.
Added benefits of drospirenone for compliance
- Medicine, BiologyClimacteric : the journal of the International Menopause Society
- 2005
Significant improvements were observed in quality of life during treatment with 1 mg 17β-estradiol/2 mg drospirenone, which also resulted in higher mean scores than estradiol alone, and that the effect on body weight is dependent on the dose of drospirnone, and this is due to droSpirenone's antimineralocorticoid activity.
Efficacy of a New Low-Dose Oral Contraceptive With Drospirenone in Premenstrual Dysphoric Disorder
- MedicineObstetrics and gynecology
- 2005
A 24/4 regimen of drospirenone 3 mg and ethinyl estradiol 20 &mgr;g improves symptoms associated with premenstrual dysphoric disorder.
Ethinylestradiol/Drospirenone
- Medicine, Biology
- 2003
Data from several 1- to 2-year studies show that EE/DRSP is an effective oral contraceptive, with Pearl index values similar to those of established low-dose CCs, and appears to be a useful treatment option for women desiring oral contraception.
Treatment of premenstrual dysphoric disorder with a new drospirenone-containing oral contraceptive formulation.
- MedicineContraception
- 2005
Drospirenone: a Novel Progestogen with Antimineralocorticoid and Antiandrogenic Activity
- Biology, MedicineAnnals of the New York Academy of Sciences
- 1995
Drospirenone exerts potent progestogenic and antigonadotropic activity which was studied in various animal species and efficiently promotes the maintenance of pregnancy in ovariectomized rats, inhibits ovulation in rats and mice and stimulates endometrial transformation in the rabbit.
Effects of two combined oral contraceptives containing ethinyl estradiol 20 microg combined with either drospirenone or desogestrel on lipids, hemostatic parameters and carbohydrate metabolism.
- Biology, MedicineContraception
- 2005
Drospirenone: pharmacology and pharmacokinetics of a unique progestogen.
- Biology, MedicineContraception
- 2000
The safety of a drospirenone-containing oral contraceptive: final results from the European Active Surveillance Study on oral contraceptives based on 142,475 women-years of observation.
- MedicineContraception
- 2007
Safety of a New Oral Contraceptive Containing Drospirenone
- MedicineDrug safety
- 2004
Overall, the safety data with EE/DRSP and other OCs indicate that these products have no negative impact on the risk of VTE (and other adverse events) in women who receive OCs for contraception.