Drospirenone, a progestogen with antimineralocorticoid properties: a short review

@article{Oelkers2004DrospirenoneAP,
  title={Drospirenone, a progestogen with antimineralocorticoid properties: a short review},
  author={Wolfgang Oelkers},
  journal={Molecular and Cellular Endocrinology},
  year={2004},
  volume={217},
  pages={255-261}
}
  • W. Oelkers
  • Published 2004
  • Medicine
  • Molecular and Cellular Endocrinology
UNLABELLED Progesterone (P) has high affinity to the mineralocorticoid receptor (MCR), and it is an MCR antagonist. Almost all synthetic progestogens are devoid of this antimineralocorticoid (anti-MC) effect. They are unable to antagonize the salt retaining effect of estrogens. This could be one cause of weight gain and an increase in blood pressure with the use of combined oral contraceptives (OC) and, in some susceptible women, with postmenopausal estrogen/(progestogen) treatment. The purpose… Expand
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The combination of 30 g ethinylestradiol/3 mg drospirenone provides effective oral contraception, excellent cycle control, good tolerability and a level of weight loss that may have a significant beneficial effect on compliance in women with a tendency to weight gain due to water retention. Expand
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