Drosotoxin, a selective inhibitor of tetrodotoxin-resistant sodium channels.

@article{Zhu2010DrosotoxinAS,
  title={Drosotoxin, a selective inhibitor of tetrodotoxin-resistant sodium channels.},
  author={Shunyi Zhu and B. Gao and Meichun Deng and Yuzhe Yuan and Lan Luo and S. Peigneur and Y. Xiao and S. Liang and J. Tytgat},
  journal={Biochemical pharmacology},
  year={2010},
  volume={80 8},
  pages={
          1296-302
        }
}
The design of animal toxins with high target selectivity has long been a goal in protein engineering. Based on evolutionary relationship between the Drosophila antifungal defensin (drosomycin) and scorpion depressant Na(+) channel toxins, we exploited a strategy to create a novel chimeric molecule (named drosotoxin) with high selectivity for channel subtypes, which was achieved by using drosomycin to substitute the structural core of BmKITc, a depressant toxin acting on both insect and… Expand
Molecular design of new sodium channel blockers.
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Molecular design of new sodium channel blockers.
  • P. Li, Shunyi Zhu
  • Chemistry, Medicine
  • Biochemical and biophysical research communications
  • 2011
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