Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation.

  title={Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation.},
  author={T P Yao and William A. Segraves and Anthony E Oro and Michael Aidan McKeown and Ronald M Evans},
  volume={71 1},
The vertebrate retinoid X receptor (RXR) has been implicated in the regulation of multiple hormonal signaling pathways through the formation of heteromeric receptor complexes that bind DNA with high affinity. We now demonstrate that ultraspiracle (usp), a Drosophila RXR homolog, can substitute for RXR in stimulating the DNA binding of receptors for retinoic acid, T3, vitamin D, and peroxisome proliferator activators. These observations led to the search and ultimate identification of the… CONTINUE READING
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