Drosophila twin spot clones reveal cell division dynamics in regenerating imaginal discs.
@article{Sustar2011DrosophilaTS, title={Drosophila twin spot clones reveal cell division dynamics in regenerating imaginal discs.}, author={Anne Sustar and Marianne Bonvin and Margrit Schubiger and Gerold Schubiger}, journal={Developmental biology}, year={2011}, volume={356 2}, pages={ 576-87 } }
27 Citations
Regeneration and transdetermination in Drosophila imaginal discs.
- BiologyAnnual review of genetics
- 2012
A historical overview of the field is presented and how the application of modern methods has made the study of disc regeneration amenable to genetic analysis is described, which could provide new insights into tissue regeneration, transdetermination and compensatory proliferation.
Drosophila Imaginal Discs as a Model of Epithelial Wound Repair and Regeneration.
- BiologyAdvances in wound care
- 2016
A complete understanding of the various wound-healing mechanisms in Drosophila will be a first step in understanding how to manage damaged human tissues and optimize healing in different clinical contexts.
Drosophila as a Model System to Study Cell Signaling in Organ Regeneration
- BiologyBioMed research international
- 2018
The signaling networks involved in regulating the variety of cellular responses that are required for discs regeneration of Drosophila melanogaster are reviewed.
The Drosophila Duox maturation factor is a key component of a positive feedback loop that sustains regeneration signaling
- BiologyPLoS genetics
- 2017
By whole-genome transcriptional profiling of regenerating tissue, a positive feedback loop that regulates the extent of regenerative growth is identified that ensures the prolonged JNK activation required for regenerateative growth.
A Positive Feedback Loop Ensures Propagation of ROS Production and JNK Signaling Throughout Drosophila Tissue Regeneration
- BiologybioRxiv
- 2017
It is shown that damage-induced JNK signaling leads to the upregulation of a gene called moladietz, which encodes a co-factor for an enzyme that generates reactive oxygen species (ROS), a key tissue-damage signal.
TIE-DYE: a combinatorial marking system to visualize and genetically manipulate clones during development in Drosophila melanogaster
- BiologyDevelopment
- 2013
The TIE-DYE method is developed that allows simultaneous lineage tracing of multiple cell populations as well as the genetic manipulation of a subset of these populations, allowing an assessment of the consequences of alterations in growth, patterning and cell-cell affinity.
Drosophila TIE-DYE : a combinatorial marking system to visualize and genetically manipulate clones during development in Drosophila melanogaster
- Biology
To understand the development of a tissue or an organ there is a need to describe the origin of cells as well as interactions between cells, and genetic systems that stochastically label cells and all of their progeny have been used to study cell lineages.
Distinct signaling signatures drive compensatory proliferation via S-phase acceleration
- BiologyPLoS genetics
- 2022
This work investigates models of compensatory proliferation in Drosophila imaginal discs and finds that compensatoryiferation is associated with a unique cell cycle profile, which is characterized by short G1 and G2 phases and, surprisingly, by acceleration of the S-phase.
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