Drosophila syndecan: conservation of a cell-surface heparan sulfate proteoglycan.

  title={Drosophila syndecan: conservation of a cell-surface heparan sulfate proteoglycan.},
  author={J C Spring and Stephenie Paine-Saunders and Richard O Hynes and Merton R. Bernfield},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={91 8},
In mammals, cell-surface heparan sulfate is required for the action of basic fibroblast growth factor, fibronectin, antithrombin III, as well as other effectors. The syndecans, a gene family of four transmembrane proteoglycans that participates in these interactions, are the major source of this heparan sulfate. Based on the conserved transmembrane and cytoplasmic domains of the mammalian syndecans, a single syndecan-like gene was detected and localized in the Drosophila genome. As in mammals… CONTINUE READING