Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling

  title={Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling},
  author={Kyu-Sun Lee and O. -Yu Kwon and Joon Ho Lee and Kisang Kwon and Kyung-jin Min and Sun-Ah Jung and Ae-kyeong Kim and Kwan-Hee You and Marc Tatar and Kweon Yu},
  journal={Nature Cell Biology},
Insulin and insulin growth factor have central roles in growth, metabolism and ageing of animals, including Drosophila melanogaster. In Drosophila, insulin-like peptides (Dilps) are produced by specialized neurons in the brain. Here we show that Drosophila short neuropeptide F (sNPF), an orthologue of mammalian neuropeptide Y (NPY), and sNPF receptor sNPFR1 regulate expression of Dilps. Body size was increased by overexpression of sNPF or sNPFR1. The fat body of sNPF mutant Drosophila had… CONTINUE READING
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