Drosophila selenophosphate synthetase 1 regulates vitamin B6 metabolism: prediction and confirmation

@inproceedings{Lee2011DrosophilaSS,
  title={Drosophila selenophosphate synthetase 1 regulates vitamin B6 metabolism: prediction and confirmation},
  author={Kwang Hee Lee and Myoung Sup Shim and Jin Young Kim and Hee Kyoung Jung and Eunjee Lee and Bradley A. Carlson and Xueming Xu and Jin Mo Park and Dolph Lee Hatfield and Taesung Park and Byeong Jae Lee},
  booktitle={BMC Genomics},
  year={2011}
}
There are two selenophosphate synthetases (SPSs) in higher eukaryotes, SPS1 and SPS2. Of these two isotypes, only SPS2 catalyzes selenophosphate synthesis. Although SPS1 does not contain selenophosphate synthesis activity, it was found to be essential for cell growth and embryogenesis in Drosophila. The function of SPS1, however, has not been elucidated. Differentially expressed genes in Drosophila SL2 cells were identified using two-way analysis of variance methods and clustered according to… CONTINUE READING