Drosophila ribosomal proteins are associated with linker histone H1 and suppress gene transcription.

@article{Ni2006DrosophilaRP,
  title={Drosophila ribosomal proteins are associated with linker histone H1 and suppress gene transcription.},
  author={Jian-Quan Ni and Lu-ping Liu and Daniel Hess and Jens Rietdorf and Fang-Lin Sun},
  journal={Genes & development},
  year={2006},
  volume={20 14},
  pages={1959-73}
}
The dynamics and function of ribosomal proteins in the cell nucleus remain enigmatic. Here we provide evidence that specific components of Drosophila melanogaster ribosomes copurify with linker histone H1. Using various experimental approaches, we demonstrate that this association of nuclear ribosomal proteins with histone H1 is specific, and that colocalization occurs on condensed chromatin in vivo. Chromatin immunoprecipitation analysis confirmed that specific ribosomal proteins are… CONTINUE READING

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