Drosophila projectin: relatedness to titin and twitchin and correlation with lethal (4) 102 CDa and bent-Dominant mutants

  title={Drosophila projectin: relatedness to titin and twitchin and correlation with lethal (4) 102 CDa and bent-Dominant mutants},
  author={Christine C. Fyrberg and Siegfried Labeit and Belinda Bullard and Kevin R. Leonard and Eric A. Fyrberg},
  journal={Proceedings of the Royal Society of London. Series B: Biological Sciences},
  pages={33 - 40}
  • C. Fyrberg, S. Labeit, E. Fyrberg
  • Published 22 July 1992
  • Biology
  • Proceedings of the Royal Society of London. Series B: Biological Sciences
We have investigated projectin, a large protein of insect muscles, in Drosophila melanogaster. The 5.3 kilobases of coding sequence reported here contains Class I and Class II motifs characteristic of titin and twitchin, arranged in a three domain ...[II–I–I] [II–I–I]... pattern. Two mutants mapped to the location of the projectin gene in the 102C subdivision of chromosome 4, lethal(4)102 CDa and bent-Dominant, have DNA rearrangements within their projectin gene. The lethal{4) 102 CDa mutant… 

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