Drosophila p53 is required to increase the levels of the dKDM4B demethylase after UV-induced DNA damage to demethylate histone H3 lysine 9.

@article{PalomeraSnchez2010DrosophilaPI,
  title={Drosophila p53 is required to increase the levels of the dKDM4B demethylase after UV-induced DNA damage to demethylate histone H3 lysine 9.},
  author={Zoraya Palomera-S{\'a}nchez and Alyeri Bucio-Mendez and Viviana Valadez-Graham and Enrique Reynaud and Mario Zurita},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 41},
  pages={31370-9}
}
Chromatin undergoes a variety of changes in response to UV-induced DNA damage, including histone acetylation. In human and Drosophila cells, this response is affected by mutations in the tumor suppressor p53. In this work, we report that there is a global decrease in trimethylated Lys-9 in histone H3 (H3K9me3) in salivary gland cells in wild type flies in response to UV irradiation. In contrast, flies with mutations in the Dmp53 gene have reduced basal levels of H3K9me3, which are then… CONTINUE READING