Drosophila p27Dacapo expression during embryogenesis is controlled by a complex regulatory region independent of cell cycle progression.

@article{Meyer2002DrosophilaPE,
  title={Drosophila p27Dacapo expression during embryogenesis is controlled by a complex regulatory region independent of cell cycle progression.},
  author={Claas Aiko Meyer and I. R. Kramer and Rainer Dittrich and Sandra Marzodko and Jan Emmerich and Christian F Lehner},
  journal={Development},
  year={2002},
  volume={129 2},
  pages={319-28}
}
dacapo encodes a CIP/KIP-type inhibitor of Cyclin E/Cdk2 complexes in Drosophila melanogaster. In the embryonic epidermis, dacapo expression starts during G2 of the final division cycle and is required for the arrest of cell cycle progression in G1 after the final mitosis. The onset of dacapo transcription is the earliest event known to be required for the epidermal cell proliferation arrest. To advance our understanding of the regulatory mechanisms that terminate cell proliferation at the… CONTINUE READING