Drosophila myc Regulates Cellular Growth during Development

@article{Johnston1999DrosophilaMR,
  title={Drosophila myc Regulates Cellular Growth during Development},
  author={L. Johnston and D. Prober and B. Edgar and R. Eisenman and P. Gallant},
  journal={Cell},
  year={1999},
  volume={98},
  pages={779-790}
}
Transcription factors of the Myc proto-oncogene family promote cell division, but how they do this is poorly understood. Here we address the functions of Drosophila Myc (dMyc) during development. Using mosaic analysis in the fly wing, we show that loss of dMyc retards cellular growth (accumulation of cell mass) and reduces cell size, whereas dMyc overproduction increases growth rates and cell size. dMyc-induced growth promotes G1/S progression but fails to accelerate cell division because G2/M… Expand
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