Drosophila microRNAs Are Sorted into Functionally Distinct Argonaute Complexes after Production by Dicer-1

@article{Frstemann2007DrosophilaMA,
  title={Drosophila microRNAs Are Sorted into Functionally Distinct Argonaute Complexes after Production by Dicer-1},
  author={Klaus F{\"o}rstemann and Michael D. Horwich and Liangmeng Wee and Yukihide Tomari and Phillip D. Zamore},
  journal={Cell},
  year={2007},
  volume={130},
  pages={287-297}
}
Small interfering RNAs (siRNAs) and microRNAs (miRNAs) guide distinct classes of RNA-induced silencing complexes (RISCs) to repress mRNA expression in biological processes ranging from development to antiviral defense. In Drosophila, separate but conceptually similar endonucleolytic pathways produce siRNAs and miRNAs. Here, we show that despite their distinct biogenesis, double-stranded miRNAs and siRNAs participate in a common sorting step that partitions them into Ago1- or Ago2-containing… CONTINUE READING
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