Drosophila melanogaster troponin-T mutations engender three distinct syndromes of myofibrillar abnormalities.

@article{Fyrberg1990DrosophilaMT,
  title={Drosophila melanogaster troponin-T mutations engender three distinct syndromes of myofibrillar abnormalities.},
  author={Eric A. Fyrberg and Christine C. Fyrberg and Clifford Beall and D. H. Saville},
  journal={Journal of molecular biology},
  year={1990},
  volume={216 3},
  pages={657-75}
}
In vertebrates troponin complexes interact co-operatively with tropomyosin dimers to modulate skeletal muscle contraction. In order further to investigate troponin assembly and function in vivo, we are developing molecular genetic approaches. Here we report characterization of the gene that encodes Drosophila tropinin-T and analyses of muscle defects engendered by several mutant alleles. We found that the Drosophila troponin-T locus specifies at least three proteins having sequences similar to… CONTINUE READING
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