Drosophila melanogaster deficient in protein kinase A manifests behavior-specific arrhythmia but normal clock function.

@article{Majercak1997DrosophilaMD,
  title={Drosophila melanogaster deficient in protein kinase A manifests behavior-specific arrhythmia but normal clock function.},
  author={John M. Majercak and Daniel Kalderon and Isaac Edery},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 10},
  pages={
          5915-22
        }
}
Drosophila melanogaster bearing mutations in the DCO gene, which encodes the major catalytic subunit of cAMP-dependent protein kinase (PKA), displays arrhythmic locomotor activity strongly suggesting a role for PKA in the circadian timing system. This arrhythmicity might result from a requirement for PKA activity in photic resetting pathways, the timekeeping mechanism itself, or downstream effector pathways controlling overt behavioral rhythms. To address these possibilities, we examined the… CONTINUE READING

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