Drosophila melanogaster as a model for study of general anesthesia: the quantitative response to clinical anesthetics and alkanes.

Abstract

Using an assay of the geotactic behavior of the fruit fly, we have quantified anesthetic effects in Drosophila melanogaster. We determined dose-responses for nine conventional anesthetics and a series of n-alkanes. For the conventional anesthetics, anesthetic potency and olive oil/gas partition coefficients are well correlated. However, as one ascends the… (More)

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