Drosophila melanogaster Thor and response to Candida albicans infection.

@article{Levitin2007DrosophilaMT,
  title={Drosophila melanogaster Thor and response to Candida albicans infection.},
  author={Anastasia Levitin and Anne Marcil and Gritta Tettweiler and Marianne Laforest and Ursula Oberholzer and Antonio Alarc{\'o} and David Y. Thomas and Paul Lasko and Malcolm Whiteway},
  journal={Eukaryotic cell},
  year={2007},
  volume={6 4},
  pages={
          658-63
        }
}
We used Drosophila melanogaster macrophage-like Schneider 2 (S2) cells as a model to study cell-mediated innate immunity against infection by the opportunistic fungal pathogen Candida albicans. Transcriptional profiling of S2 cells coincubated with C. albicans cells revealed up-regulation of several genes. One of the most highly up-regulated genes during this interaction is the D. melanogaster translational regulator 4E-BP encoded by the Thor gene. Analysis of Drosophila 4E-BP(null) mutant… CONTINUE READING

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