Drosophila melanogaster NEP2 is a new soluble member of the neprilysin family of endopeptidases with implications for reproduction and renal function.

@article{Thomas2005DrosophilaMN,
  title={Drosophila melanogaster NEP2 is a new soluble member of the neprilysin family of endopeptidases with implications for reproduction and renal function.},
  author={Josie E Thomas and Caroline M Rylett and Ahmet Carhan and Nicholas D. Bland and Richard J Bingham and Alan D. Shirras and Anthony J. Turner and R Elwyn Isaac},
  journal={The Biochemical journal},
  year={2005},
  volume={386 Pt 2},
  pages={357-66}
}
The mammalian neprilysin (NEP) family members are typically type II membrane endopeptidases responsible for the activation/inactivation of neuropeptides and peptide hormones. Differences in substrate specificity and subcellular localization of the seven mammalian NEPs contribute to their functional diversity. The sequencing of the Drosophila melanogaster genome has revealed a large expansion of this gene family, resulting in over 20 fly NEP-like genes, suggesting even greater diversity in… CONTINUE READING

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