Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis.

@article{Sokol2008DrosophilaLM,
  title={Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis.},
  author={Nicholas Samuel Sokol and Peizhang Xu and Yuh Nung Jan and Victor Robert Ambros},
  journal={Genes & development},
  year={2008},
  volume={22 12},
  pages={1591-6}
}
The Drosophila let-7-Complex (let-7-C) is a polycistronic locus encoding three ancient microRNAs: let-7, miR-100, and fly lin-4 (miR-125). We find that the let-7-C locus is principally expressed in the pupal and adult neuromusculature. let-7-C knockout flies appear normal externally but display defects in adult behaviors (e.g., flight, motility, and fertility) as well as clear juvenile features in their neuromusculature. We find that the function of let-7-C to ensure the appropriate remodeling… CONTINUE READING
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