Drosophila lamin mutations cause melanotic mass formation and lamellocyte differentiation.

@article{Markovic2009DrosophilaLM,
  title={Drosophila lamin mutations cause melanotic mass formation and lamellocyte differentiation.},
  author={Maja Pavlovic Markovic and Per Kylsten and Mitchell S. Dushay},
  journal={Molecular immunology},
  year={2009},
  volume={46 16},
  pages={
          3245-50
        }
}
The fruit fly immune system is a valuable model for invertebrate and innate immunity. Cellular immune reactions in Drosophila are of great interest, especially the molecular genetic mechanisms of hemocyte differentiation and the encapsulation of foreign bodies. Here we report that changes in the lamin gene cause melanotic masses. These darkened clusters of cells result from autoimmune-like encapsulation of self-tissue, as shown by the presence in lam larvae of lamellocytes, effector hemocytes… CONTINUE READING
BETA

References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES

Mouse models of the laminopathies

  • M. R. Strand
  • Experimental Cell Research
  • 2008
Highly Influential
3 Excerpts

Drosophila haematopoiesis

  • M. rozatier, M. Meister
  • Cellular Microbiology
  • 2007

Similar Papers

Loading similar papers…