Drosophila immunity: genes on the third chromosome required for the response to bacterial infection.

  title={Drosophila immunity: genes on the third chromosome required for the response to bacterial infection.},
  author={Louisa P. Wu and K M Choe and Yong Lu and Kathryn V Anderson},
  volume={159 1},
We have screened the third chromosome of Drosophila melanogaster for mutations that prevent the normal immune response. We identified mutant lines on the basis of their failure to induce transcription of an antibacterial peptide gene in response to infection or their failure to form melanized clots at the site of wounding. These mutations define 14 genes [immune response deficient (ird) genes] that have distinct roles in the immune response. We have identified the molecular basis of several ird… CONTINUE READING
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