Drosophila immunity: a comparative analysis of the Rel proteins dorsal and Dif in the induction of the genes encoding diptericin and cecropin.

@article{Gross1996DrosophilaIA,
  title={Drosophila immunity: a comparative analysis of the Rel proteins dorsal and Dif in the induction of the genes encoding diptericin and cecropin.},
  author={Isabelle Mercedes Gross and Philippe Georgel and Christine Kappler and J M Reichhart and Jules A. Hoffmann},
  journal={Nucleic acids research},
  year={1996},
  volume={24 7},
  pages={1238-45}
}
In Drosophila, bacterial challenge induces the rapid transcription of several genes encoding potent antibacterial peptides. The upstream sequences of the diptericin and cecropin Al genes, which have been investigated in detail, contain two, respectively one sequence element homologous to the binding site of the mammalian nuclear factor kappaB. These elements have been shown to be mandatory for immune-induced transcription of both genes. Functional studies have shown that these kappaB-related… CONTINUE READING

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Immune Gene Expression in Drosophila

  • M. Meister, P. Georgel, +4 authors J. A. Hoffmann
  • 1994

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