Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms.

@article{Lemaitre1997DrosophilaHD,
  title={Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms.},
  author={Bruno Lemaitre and J M Reichhart and Jules A. Hoffmann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 26},
  pages={14614-9}
}
Insects respond to microbial infection by the rapid and transient expression of several genes encoding potent antimicrobial peptides. Herein we demonstrate that this antimicrobial response of Drosophila is not aspecific but can discriminate between various classes of microorganisms. We first observe that the genes encoding antibacterial and antifungal peptides are differentially expressed after injection of distinct microorganisms. More strikingly, Drosophila that are naturally infected by… CONTINUE READING
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