Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification.

@article{Boube2000DrosophilaHO,
  title={Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification.},
  author={Muriel Boube and Catherine Faucher and Laurent Joulia and David L. Cribbs and Henri Bourbon},
  journal={Genes & development},
  year={2000},
  volume={14 22},
  pages={
          2906-17
        }
}
The origins of specificity in gene expression are a central concern in understanding developmental control. Mediator protein complexes regulate transcriptional initiation, acting as modular adaptors linking specific transcription factors to core RNA polymerase II. Here, we identified the Drosophila homologs of 23 human mediator genes and mutations of two, dTRAP240 and of dTRAP80 (the putative fly homolog of yeast SRB4). Clonal analysis indicates a general role for dTRAP80 necessary for cell… CONTINUE READING
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