Drosophila histone H2A variant (H2Av) controls poly(ADP-ribose) polymerase 1 (PARP1) activation in chromatin.

@article{Kotova2011DrosophilaHH,
  title={Drosophila histone H2A variant (H2Av) controls poly(ADP-ribose) polymerase 1 (PARP1) activation in chromatin.},
  author={E. Yu. Kotova and Niraj Lodhi and Michael Jarnik and Aaron D. Pinnola and Yingbiao Ji and Alexei V. Tulin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 15},
  pages={
          6205-10
        }
}
  • E. Yu. Kotova, Niraj Lodhi, +3 authors Alexei V. Tulin
  • Published in
    Proceedings of the National…
    2011
  • Biology, Medicine
  • According to the histone code hypothesis, histone variants and modified histones provide binding sites for proteins that change the chromatin state to either active or repressed. Here, we identify histone variants that regulate the targeting and enzymatic activity of poly(ADP-ribose) polymerase 1 (PARP1), a chromatin regulator in higher eukaryotes. We demonstrate that PARP1 is targeted to chromatin by association with the histone H2A variant (H2Av)--the Drosophila homolog of the mammalian… CONTINUE READING

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