Drosophila glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc.

@article{Han2005DrosophilaGD,
  title={Drosophila glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc.},
  author={Chun Han and Dong Yan and Tatyana Y. Belenkaya and Xinhua Lin},
  journal={Development},
  year={2005},
  volume={132 4},
  pages={667-79}
}
Drosophila Wingless (Wg) is the founding member of the Wnt family of secreted proteins. During the wing development, Wg acts as a morphogen whose concentration gradient provides positional cues for wing patterning. The molecular mechanism(s) of Wg gradient formation is not fully understood. Here, we systematically analyzed the roles of glypicans Dally and Dally-like protein (Dlp), the Wg receptors Frizzled (Fz) and Fz2, and the Wg co-receptor Arrow (Arr) in Wg gradient formation in the wing… CONTINUE READING
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