Drosophila glucosylceramide synthase: a negative regulator of cell death mediated by proapoptotic factors.

@article{KohyamaKoganeya2004DrosophilaGS,
  title={Drosophila glucosylceramide synthase: a negative regulator of cell death mediated by proapoptotic factors.},
  author={Ayako Kohyama-Koganeya and Takeshi Sasamura and Eriko Oshima and Emiko Suzuki and Shoko Nishihara and Ryu Ueda and Yoshio Hirabayashi},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 34},
  pages={35995-6002}
}
Glucosylceramide synthase (GlcT-1) catalyzes the formation of glucosylceramide (GlcCer), the core structure of major glycosphingolipids (GSLs), from ceramide and UDP-glucose. Ceramide and its metabolites, such as sphingosine-1-phosphate, are now known to be important mediators of apoptosis and cell survival. Recently, we have shown that GlcT-1 functions to regulate intracellular ceramide levels via glycosylation of ceramide. In this study, we employ the fruit fly Drosophila melanogaster as a… CONTINUE READING