Drosophila fasciclin I is a novel homophilic adhesion molecule that along with fasciclin III can mediate cell sorting

@article{Elkins1990DrosophilaFI,
  title={Drosophila fasciclin I is a novel homophilic adhesion molecule that along with fasciclin III can mediate cell sorting},
  author={Tina P Elkins and Michael Hortsch and Allan J Bieber and Peter M. Snow and Corey S. Goodman},
  journal={The Journal of Cell Biology},
  year={1990},
  volume={110},
  pages={1825 - 1832}
}
Fasciclin I is a membrane-associated glycoprotein that is regionally expressed on a subset of fasciculating axons during neuronal development in insects; it is expressed on apposing cell surfaces, suggesting a role in specific cell adhesion. In this paper we show that Drosophila fasciclin I is a novel homophilic cell adhesion molecule. When the nonadhesive Drosophila S2 cells are transfected with the fasciclin I cDNA, they form aggregates that are blocked by antisera against fasciclin I. When… CONTINUE READING

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